Some people blame obesity on their genes – for good reason. There is some evidence that genetics play a role in obesity and weight gain, but “inherited obesity” may actually be more a product of the Western diet that most Americans eat. A recent study published in Journal of Lipid Research took a closer look at this issue – and came to some interesting conclusions.
Inherited Obesity and the Western Diet 
There’s no doubt that the Western diet is high in fat, but it also has the wrong fat ratios. Polyunsaturated fats, which are healthier from a cardiac standpoint than saturated fatty acids, are made up of omega-3 and omega-6 fatty acids. The typical Western diet has a very high ratio of omega-6 to omega-3 fatty acids. Studies show this is less healthy than having a lower ratio – and it also increases whole body inflammation, which is a risk factor for some diseases.
This is one reason why more people are supplementing their diets with omega-3 fatty acids – to help reduce the inflammation which can lead to diseases like heart disease and cancer. The ideal ratio of omega-6 to omega-3 fatty acids is four to one. Needless to say, the typical Western diet has a far greater ratio with some Americans consuming diets that have 40 to 1 up to a 200 to 1 ratio of omega-6 to omega-3
Inherited Obesity and ALA Deficiency
Researchers tested the effects of eating a Western diet on mice over several generations by giving them a diet high in the omega-6 fatty acid, alpha-linoleic-acid, or ALA. The mice were allowed to eat as much of this ALA-rich diet as they wanted – to mimic a typical Western diet. On this diet, the rate of obesity in these mice gradually increased over four generations of breeding.
What accounted for this increase? Researchers believe the high omega-6 diet these mice ate caused changes in genes that regulate growth of fat cells, so that the effects would be passed down from generation to generation – thereby accounting for some cases of “inherited obesity”.
Inherited Obesity and Omega-6 Fatty Acids: The Bottom Line
It’s an interesting concept that diet could not only cause weight gain in an animal, but the effects could be passed on to future generations through changes in genes that control fat tissue growth. Does the same apply to humans? Hopefully, future research will determine this – but one thing is certain. A Western diet not only increases the risk of obesity, but diabetes and heart disease as well. It’s not the best choice for overall health.
References:
NutraingredientsUSAwebsite. “Insufficient ALA could be linked to obesity trend”
